Spatial regulation of controlled bioactive factor delivery for bone tissue engineering
نویسندگان
چکیده
منابع مشابه
Bioactive Glass Scaffolds for Bone Tissue Engineering
In materials science, the ability to develop porous constructs with high mechanical strength is important for a broad range of emerging applications, including filters, catalyst support, and tissue engineering scaffolds. Particularly for orthopedic surgery, the regeneration of large bone defects in load-bearing limbs remains a challenging problem that require scaffolds that combine the strength...
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Bioactive glasses are useful materials as synthetic bone graft substitutes due to their potential for osseoinduction and osseoconduction. The ability of these materials to chemically bond to bone is characterized by surface apatite formation. In this paper, the bioactivity of two bioactive glasses has been evaluated in serum supplemented cell culture medium simulating near-physiological conditi...
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Tissue development and regeneration is regulated by an interplay among various tissue inductive growth factors, formation of an appropriate vascular bed to support the metabolic needs of the forming tissue mass, and a cell population capable of responding to the chemical cues and creating the new tissue. There has been considerable interest in understanding this signaling interplay in bone, due...
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The current investigation was aimed at identifying the role of mesoporous wollastonite particles on the healing of rat tibial bone defect. The bone defect was created with a 3-mm-diameter dental drill, and it was filled with mesoporous wollastonite particles. After second and fourth weeks of filling treatments, it was found that mesoporous wollastonite particles promoted bone formation as evide...
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Herein we describe a method to fabricate submicron bioactive glass tubes using sol-gel and coaxial electrospinning techniques for applications in bone tissue engineering. Heavy mineral oil and gel solution were delivered by two independent syringe pumps during the coaxial electrospinning process. Subsequently, submicron bioactive glass tubes were obtained by removal of poly(vinyl pyrrolidone) a...
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ژورنال
عنوان ژورنال: Advanced Drug Delivery Reviews
سال: 2015
ISSN: 0169-409X
DOI: 10.1016/j.addr.2014.11.018